WG5

Working Group 5

Public web resources

WG5 will integrate and avail experimental data emanating from the Action and global field. This will disseminate results widely and sustainable, and inspire and equip the most valuable new studies to expand the coverage of receptors targets and pathways within the field. So far, work on the follow resources have been initiated:

01. Biased ligands in a database of reference probes.

02. An atlas of pathway physiological/therapeutic effects to inform the development of functionally selective probes/drugs.

03. A database of molecular dynamics trajectories to investigate the role of receptor dynamics in ligand-receptor activation and signal transduction.

04. Reference structures and sequence alignments, for GPCRs, G proteins and arrestins.

05. Data-driven tools to design new experiments, such as in vitro mutations to elucidate molecular mechanisms of chemical probes on signalling protein machineries

As the community and data grows, further online data and tools will be tailored together with the research community to define additional joint development-data generation projects and to raise the funding needed.

REFERENCES

01. Flock, T., Hauser, A.S., Lund, N., Gloriam, D.E., Balaji, S. and Babu, M.M. (2017) Selectivity determinants of GPCR-G-protein binding. Nature, 545, 317-322.

02. Pandy-Szekeres, G., Munk, C., Tsonkov, T.M., Mordalski, S., Harpsoe, K., Hauser, A.S., Bojarski, A.J. and Gloriam, D.E. (2018) GPCRdb in 2018: adding GPCR structure models and ligands. Nucleic Acids Res, 46, D440-D446.

03. Harding, S.D., Sharman, J.L., Faccenda, E., Southan, C., Pawson, A.J., Ireland, S., Gray, A.J.G., Bruce, L., Alexander, S.P.H., Anderton, S., Bryant, C., Davenport, A.P., Doerig, C., Fabbro, D., Levi-Schaffer, F., Spedding, M. and Davies, J.A. (2017) The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY. Nucleic Acids Res., gkx1121-gkx1121.

04. Bento, A.P., Gaulton, A., Hersey, A., Bellis, L.J., Chambers, J., Davies, M., Krüger, F.A., Light, Y., Mak, L., McGlinchey, S., Nowotka, M., Papadatos, G., Santos, R. and Overington, J.P. (2014) The ChEMBL bioactivity database: an update. Nucleic Acids Res., 42, D1083-1090.

05. Isberg, V., de Graaf, C., Bortolato, A., Cherezov, V., Katritch, V., Marshall, F.H., Mordalski, S., Pin, J.P., Stevens, R.C., Vriend, G. and Gloriam, D.E. (2015) Generic GPCR residue numbers – aligning topology maps while minding the gaps. Trends Pharmacol. Sci., 36, 22-31.

WORK GROUP LEADERS

Prof David Gloriam
WG5 Leader
PT
University of Copenhagen
david.gloriam@sund.ku.dk

Dr Jana Selent
WG5 vice-Leader
CHE
IMIM Hospital del Mar Medical Research Institute
jana.selent@upf.edu

COST

COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation.

COST Action CA18133

All cells face the vital challenge of sensing their environments and responding in appropriate ways. How are different signalling pathways activated and modulated in precise and reproducible ways? Filling this gap in knowledge is absolutely necessary to advance the next generation of pharmaceutical drugs.

COST Action

COST Action

Pulpit rock

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