WG1 + WG2 survey – signal transduction pathways

Proteins of interest:	Signal transduction pathway(s) and/or protein-protein interaction of interest:	Cellular response(s) of interest:	Last name:	First name:	Contact e-mail:	Institution/University:	Country:
G protein-coupled receptors	G protein signaling, arrestin recruitment	Secretion, tumorigenesis	Abboud	Dayana		University of Liege	Belgium
Class C GPCRs			Acher	Francine		University of Paris/CNRS	France
Adrenergic receptors, GnRHR, GPR54, LHCGR, FSHR		Mitochondrial dynamics, fertilization, reproductive hormones homeostasis	Andric	Silvana		University of Novi Sad Faculty of Sciences	Serbia
TASR	Bitter compounds AND TAS2R	Enterohormone secretion	Ardevol	Anna		Universitat Rovira i Virgili	Spain
Food proteins, receptor proteins that sense food/nutrients	Receptors/transporters that sense nutrients in the human gastrointestinal tract	Endocrine system, intestinal system, GPCR responses, intestinal responses	Bastiaan-Net	Shanna		Wageningen UR; Food & Biobased Research	Netherlands
GPCRs	G protein-arrestin dichotomy	Second messenger production, cell morphological changes, receptor desensitization	Benkel	Tobias		University of Bonn	Germany
MC4R	Gs, Gq; G12/13, MRAP2		Biebermann	Heike		Charite University Medicine Berlin	Germany
Orphan GPCRs such as GPR160, GPR141	G protein pathways	cAMP, FRET	Birgul	Necla		University of Bogazici	Turkey
Sonic Hedgehog	Hedgehog signaling pathway. Proteins: Sonic Hedgehog, Smoothened, Patched	Expression of GLI transcription factor	Blanco-Canosa	Juan Bautista		Institute for Advanced Chemistry of Catalonia (IQAC-CSIC)	Spain
GPCR (LHR, FSHR, OXTR, Vasopressin R, MTR)	cAMP, IP3, beta-arrestin, Calcium, EPAC	Steroid secretion	Bozon	Veronique		INRAe and University of Tours	France
Leukotriene and ghrelin receptors			Catoire	Laurent		CNRS/University of Paris	France
Class A GPCRs	Biased signaling	Biased signaling	Chabbert	Marie		CNRS	France
Opioid Receptors, RGS proteins, Arrestins, Spinophilin	Novel Signaling Pathways of Opioid Receptors- Role of interactive proteins	Receptor activation, Desensitization, Autophagy, Endosomal signaling	Georgoussi	Zafiroula (Iro)		Institute of Biosciences and Applications/National Centre for Scientific Research "Demokritos"	Greece
OXTR, AVPRs, CB2R, KOR	IP1, cAMP, Ca2+	Proliferation, immune function	Gruber	Christian		Medical University of Vienna	Austria
Neuropsychiatric GPCRs, Class B1, G proteins	Generally GPCR-G protein interface	G protein activation and Arrestin recruitment	Hauser	Alexander		University of Denmark	Denmark
G-protein molecules	Arachidonic acid pathway	Inflammatory cells	Hoxha	Malvina		Catholic University Our Lady of Good Counsel	Albania
G-protein coupled receptors	G-protein, arrestin	G-protein activation	Hunyady	Laszlo		Research Centre for Natural Sciences	Hungary
GPCRs, Adenylate cyclase, PKA, phosphodiesterase, beta-arrestin, GRKs	Gs/cAMP/PKA, beta-Arrestin-GPCR interaction, GRKs	cAMP, PKA, gene expression, steroidogenesis	Jean-Alphonse	Frederic		CNRS	France
GPR37, Muscarinic Aceytlcholine Receptors, G proteins, proteins involved in autophagy and mitophagy, including ATG3	Pathways and proteins related to the proteins listed above	Autophagy and mitophagy, inflammation	Kan	Beki		Acibadem University	Turkey
GPR120; GPR21; CXCR4			Kinsella	Gemma		TU Dublin	Ireland
Beta2AR, M2,3AR, OXRs, PTH1R, opioids, CXCRs	G proteins, arrestins, GRKs		Kolb	Peter		Philipps-University Marburg	Germany
Membrane proteins (Adenosine receptors, P2X7, MmpL3, viroporins)	GPCR-Gi or arrestin	Any	Kolocouris	Antonios		National and Kapodistrian University of Athens, Pharmacy	Greece
Muscarinic (M1,2,4), dopaminergic (D2,3) and melanocortin (MC4) receptors	G-protein coupled pathway	cAMP response	Laasfeld	Tonis		University of Tartu	Estonia
Class B GPCRs	cAMP-dependent pathway, peptide-protein interactions	Regulation of gene expression	Latek	Dorota		University of Warsaw	Poland
Adhesion GPCRs (especially family ADGRG), CMKLR1, PAR, Y receptor			Liessmann	Fabian		Institute for Drug Discovery	Germany
GHSR-1a	Interaction with intra-cellular partner : G-protein, beta-Arrestin, regulatory proteins		Louet	Maxime		University of Montpellier	France
Purine receptors, orphan GPCRs	G protein signaling (all pathways), beta-arrestin translocation, new signaling paradigms	cAMP, Ca2+, beta-arrestin recruitment, microscopically visible changes	Mueller	Christa		University of Bonn	Germany
GPCRs, RAMPs	GPCR-RAMP	Beta-arrestin, cAMP	Nemec	Katarina		MDC Berlin	Germany
AT1R, TXA2R	AT1R - TXA2R Heterodimerization	FRET	Olgac	Abdurrahman		Gazi University	Turkey
Orphan GPCRs (GPR37), Chemokine receptors, Spingosine 1 phosphate receptors	MAPK, Autophagy pathway, Atg3 protein interaction partners	Autophagy, cellular metabolism (mitochondria), Endosomal trafficking	Oz-Arslan	Devrim		Acibadem University	Turkey
Muscarinic and dopaminergic receptors	Physiological role of voltage dependence of GPCRs		Parnas	Moshe		Tel Aviv University	Israel
Viral GPCRs	Gq signaling, G12/13 signaling, Hippo signaling	Calcium mobilisation, cell proliferation, cancer growth	Pfeil	Eva		Vrije Universiteit Amsterdam	Netherlands
GPCRs (chemokine receptors, especially CXCR3), arrestins, G proteins	Arrestin-mediated signaling		Rajagopal	Sudarshan		Duke University School of Medicine	USA
GPCR (muscarinic, dopamine, melanocortine, NP Y, LH, FSH, Fzl), sigma1 receptor, G(alpha)	Ligand binding (also big, protein type ligands), receptor-G protein interactions (subtype selectivity)	Activation/inhibition of cAMP (response to measure for all G proteins (using modified proteins))	Rinken	Ago		University of Tartu	Estonia
M1 muscarinic acetylcholine receptor	GPCR phosphorylation-mediated pathways		Scarpa	Miriam		University of Glasgow	United Kingdom
CXCR4 and ACKR3	G proteins and beta-arrestins	Migration	Schlecht	Geraldine		University Paris-Saclay	France
Atypical Chemokine Receptors (ACKRs)	Signaling by ACKRs	Cell migration	Thelen	Marcus		Institute for Research in Biomedicine, Universita della Svizzera Italiana	Switzerland
BRAF, CRAF, NRAS, KSR, MEK, ERK, DUSP6, MDM2, MDM4, p53, eIF4A, eIF4F, mTOR, LAMTOR	ERK MAPK (RAS/RAF/MEK/ERK), BRAF-KSR, CRAF-KSR, BRAF-AMPK, CRAF-AMPK, MDM2-MDM4	Proliferation, apoptosis, necroptosis, glycolysis, oxidative phosphorylation/mitochondrial respiration	Uldrijan	Stjepan		Masaryk University	Czech Republic
GPCRs			Vanden Broeck	Jozef		KU Leuven	Belgium
Cell surface receptors of natural killer cells and other lymphocytes, and their ligands	Activation/inhibition of NK cell cytotoxicity, interactions of NK cell receptors with their protein ligands	NK cell or cytotoxic T cell response to cancer, i.e., killing of tumour cells	Vanek	Ondrej		Charles University, Faculty of Science	Czech Republic
Adrenergic receptors, free fatty acid receptors (FFARs), lactate receptors, adhesion GPCRs (GPR56, latrophilins)	Calcium, cAMP signals, etc.	Metabolism, exocytosis, morphology	Vardjan	Nina		University of Ljubljana, Faculty of Medicine	Slovenia
Sigma-1 chaperone protein	Sigma-1 chaperone AND GABA-B receptor		Vavers	Edijs		Latvian Institute of Organic Synthesis	Latvia
Arrestins	G-protein-mediated signaling		Vrecl	Milka		University of Ljubljana	Slovenia
GPCRs with biased ligands; angiotensin receptor; chemokine receptors			Wingler	Laura		Duke University	United States
Cystatins, stefins, protease inhibitors		Proteostasis	Zerovnik	Eva		Josef Stefan Institute	Slovenia