Survey for WG3 ERNEST researchers

WG3 - Molecular Modulators of Signal Transduction

  • Are you a WG3 researcher? Do you want to collaborate with ERNEST members? Filling out the following forms, you will provide information about your competencies, tools, materials, and ideas and promote collaborations within the ERNEST community.




  • PART 1. Your contributions to new collaborations (upon request)

    Briefly describe below how your group/organization could contribute to new one-to-one or multicentre collaborations. Only non-confidential data/information should be disclosed here.
  • MATERIALS

    Your potential contributions to the material (available in house):

    • Type Yes / No If yes, describe here the details
    • In house (synthetic) chemical library/collection
    • Compounds available in digital format for sharing upon request
    • Homology models or X-ray structures (unpublished) in digital format for sharing upon request
    • Cell lines and other biological material
    • Lead/Hit GPCR modulators
    • Target GPCRs
    • Other
  • SCREENING ACTIVITY

    Your potential contributions to the screening and analysis:

    • Type Yes / No If yes, describe here the details
    • Developing novel GPCR-based screening
    • Existing GPCR-based screening
    • Other bioactivity screening
    • High throughput screen/assay
    • Computational virtual screening (CADD, machine learning)
    • In vitro ADME-Tox profiling (Drug-likeness assessment)
    • In vivo models: efficacy, PK, PD
    • Other
  • MEDICINAL CHEMISTRY ACTIVITY

    Your potential contributions to the medicinal chemistry and analysis:

    • Type Yes / No If yes, describe here the details (incl. scale, techniques available)
    • In silico structure-based or ligand-based drug design/QSAR modeling
    • Other Molecular Modeling activities
    • Synthetic Medicinal chemistry: hit/lead compounds
    • Scale-up of optimized compounds
    • Chemical analysis
    • Preformulation studies
    • Other
  • PRECLINAL CANDIDATE DEVELOPMENT

    Your potential contributions to the preclinical candidate development:

    • In vitro metabolism in hepatocytes
    • Extended compound profiling: Receptors, ion channels, enzymes, CYP, hERG
    • In vitro Genetic tox studies
    • API Process Development
    • Preliminary Formulation Development
    • Bioanalytical method development
    • PK study in the non-rodent tox species
    • DRF/MTD: preliminary non-GLP tox study in a rodent and a non-rodent species
    • API Manufacturing
    • Drug Product Supply
    • Other
  • PHASE I CLINICAL STUDIES

    Your potential contributions to the Phase I clinical studies:

    • Activity
    • YES/NO
    • If yes, describe here the details (incl. scale, techniques available)
  • PART 2. Ongoing GPCR-based projects looking for specific contributions and/or available for multi-centre grant proposal

    Briefly describe below ongoing research projects in your group available for multicentre collaborations or looking for specific contributions. Only non-confidential data/information should be disclosed here.
  • PROJECT-1

    Do you have project idea or running project that would benefit from collaboration within WG3? If so, please provide a brief description of the project goals

  • Are you looking for a specific contribution to this project? (If yes, describe what are you looking for)

  • Are you planning to expand and exploit this project for a multicentre grant proposal? If yes, describe what are you looking for)

  • Is this project somehow related to the COVID-19 pandemic?

  • PROJECT-2

    Do you have project idea or running project that would benefit from collaboration within WG3? If so, please provide a brief description of the project goals

  • Are you looking for a specific contribution to this project? (If yes, describe what are you looking for)

  • Are you planning to expand and exploit this project for a multicentre grant proposal? If yes, describe what are you looking for)

  • Is this project somehow related to the COVID-19 pandemic?

  • Add More Projects

  • PROJECT IDEA/GOALSAre you looking for a specific contribution to this project? (If yes, describe what are you looking for)Are you planning to expand and exploit this project for a multicentre grant proposal? If yes, describe what are you looking for)Is this project somehow related to the COVID-19 pandemic? 
  • THANK YOU FOR YOUR TIME!

COST

COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation.

COST Action CA18133

All cells face the vital challenge of sensing their environments and responding in appropriate ways. How are different signalling pathways activated and modulated in precise and reproducible ways? Filling this gap in knowledge is absolutely necessary to advance the next generation of pharmaceutical drugs.

COST Action

COST Action

Pulpit rock

© 2019 ERNEST - All rights reserved. | Design by Boutik

European Research Network on Signal Transduction