WG3 - Molecular Modulators of Signal Transduction Are you a WG3 researcher? Do you want to collaborate with ERNEST members? Filling out the following forms, you will provide information about your competencies, tools, materials, and ideas and promote collaborations within the ERNEST community. PARTNER NAME/INSTITUTION: RESEARCH GROUP NAME INSTITUTION EMAIL HiddenPART 1. Your contributions to new collaborations (upon request) Briefly describe below how your group/organization could contribute to new one-to-one or multicentre collaborations. Only non-confidential data/information should be disclosed here.MATERIALS Your potential contributions to the material (available in house): Type Yes / No If yes, describe here the details In house (synthetic) chemical library/collection Yes No DetailsCompounds available in digital format for sharing upon request Yes No DetailsHomology models or X-ray structures (unpublished) in digital format for sharing upon request Yes No DetailsCell lines and other biological material Yes No DetailsLead/Hit GPCR modulators Yes No DetailsTarget GPCRs Yes No DetailsOther Yes No DetailsSCREENING ACTIVITY Your potential contributions to the screening and analysis: Type Yes / No If yes, describe here the details Developing novel GPCR-based screening Yes No DetailsExisting GPCR-based screening Yes No DetailsOther bioactivity screening Yes No DetailsHigh throughput screen/assay Yes No DetailsComputational virtual screening (CADD, machine learning) Yes No DetailsIn vitro ADME-Tox profiling (Drug-likeness assessment) Yes No DetailsIn vivo models: efficacy, PK, PD Yes No DetailsOther Yes No DetailsMEDICINAL CHEMISTRY ACTIVITY Your potential contributions to the medicinal chemistry and analysis: Type Yes / No If yes, describe here the details (incl. scale, techniques available) In silico structure-based or ligand-based drug design/QSAR modeling Yes No DetailsOther Molecular Modeling activities Yes No DetailsSynthetic Medicinal chemistry: hit/lead compounds Yes No DetailsScale-up of optimized compounds Yes No DetailsChemical analysis Yes No DetailsPreformulation studies Yes No DetailsOther Yes No DetailsPRECLINAL CANDIDATE DEVELOPMENT Your potential contributions to the preclinical candidate development:In vitro metabolism in hepatocytes Yes No DetailsExtended compound profiling: Receptors, ion channels, enzymes, CYP, hERG Yes No DetailsIn vitro Genetic tox studies Yes No detailsAPI Process Development Yes No DetailsPreliminary Formulation Development Yes No DetailsBioanalytical method development Yes No DetailsPK study in the non-rodent tox species Yes No DetailsDRF/MTD: preliminary non-GLP tox study in a rodent and a non-rodent species Yes No DetailsAPI Manufacturing Yes No DetailsDrug Product Supply Yes No DetailsOther Yes No PHASE I CLINICAL STUDIES Your potential contributions to the Phase I clinical studies:ActivityYES/NOIf yes, describe here the details (incl. scale, techniques available) Yes No Details Yes No Details Yes No Details Yes No Details Yes No Details Yes No DetailsPART 2. Ongoing GPCR-based projects looking for specific contributions and/or available for multi-centre grant proposal Briefly describe below ongoing research projects in your group available for multicentre collaborations or looking for specific contributions. Only non-confidential data/information should be disclosed here.PROJECT-1 Do you have project idea or running project that would benefit from collaboration within WG3? If so, please provide a brief description of the project goals Are you looking for a specific contribution to this project? (If yes, describe what are you looking for)Are you planning to expand and exploit this project for a multicentre grant proposal? If yes, describe what are you looking for)Is this project somehow related to the COVID-19 pandemic?PROJECT-2 Do you have project idea or running project that would benefit from collaboration within WG3? If so, please provide a brief description of the project goals Are you looking for a specific contribution to this project? (If yes, describe what are you looking for) Are you planning to expand and exploit this project for a multicentre grant proposal? If yes, describe what are you looking for) Is this project somehow related to the COVID-19 pandemic?Add More ProjectsPROJECT IDEA/GOALSAre you looking for a specific contribution to this project? (If yes, describe what are you looking for)Are you planning to expand and exploit this project for a multicentre grant proposal? If yes, describe what are you looking for)Is this project somehow related to the COVID-19 pandemic? THANK YOU FOR YOUR TIME!