Scientific Output

Determinants of Orexin Receptor Binding and Activation—A Molecular Dynamics Study
Lasse Karhu, Aniket Magarkar, Alex Bunker, Henri Xhaard
J. Phys. Chem. B (2019), 123, 2609−2622; DOI: 10.1021/acs.jpcb.8b10220

Cartography of rhodopsin-like G protein-coupled receptors across vertebrate genomes
Maiju Rinne, Zia-Ur-Rehman Tanoli, Asifullah Khan, Henri Xhaard
Sci. Rep. (2019), vol 9, Article number: 7058; DOI: 10.1038/s41598-018-33120-8

Docking Finds GPCR Ligands in Dark Chemical Matter
Flavio Ballante, Axel Rudling, Alexey Zeifman, Andreas Luttens, Duy Duc Vo, John J. Irwin, Jan Kihlberg, Jose Brea, Maria Isabel Loza, Jens Carlsson
J. Med. Chem. (2019); DOI: 10.1021/acs.jmedchem.9b01560

Computational design and characterization of nanobody-derived peptides that stabilize the active conformation of the β2-adrenergic receptor (β2-AR)
Milan Sencanski, Sanja Glisic, Marko Šnajder, Nevena Veljkovic, Nataša Poklar Ulrih, Janez Mavri, Milka Vrecl
Sci. Rep. (2019), vol 9, Article number: 16555; DOI: 10.1038/s41598-019-52934-8

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling
Martha E. Sommer, Jana Selent Jens Carlsson, Chris De Graaf, David E. Gloriam, Gyorgy M. Keseru, Mickey Kosloff, Stefan Mordalski, Aurelien Rizk, Mette M. Rosenkilde, Eddy Sotelo, Johanna K. S. Tiemann, Andrew Tobin, Nina Vardjan, Maria Waldhoer, Peter Kolb
ACS Pharmacol. Transl. Sci. 2020, epub ahead of print; DOI: 10.1021/acsptsci.0c00024

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COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation.

COST Action CA18133

All cells face the vital challenge of sensing their environments and responding in appropriate ways. How are different signalling pathways activated and modulated in precise and reproducible ways? Filling this gap in knowledge is absolutely necessary to advance the next generation of pharmaceutical drugs.

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